解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.2.231
更新日期:1994-08-01 00:00:00
abstract::Gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. In order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor DNAs from 31 patients - including 26 who had undergone ne...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.2.309
更新日期:1994-08-01 00:00:00
abstract::In the study of 69 matched pairs of lung tumors and normal lung parenchyma, the median activities of cathepsin B (CB) and cystein proteinase inhibitors (CPI's) in tumors were found to be increased 4.4-fold and twofold, respectively. The levels of CB and CPI activities did not correlate with TNM stages nor with cell di...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.1.77
更新日期:1994-07-01 00:00:00
abstract::Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1219
更新日期:1994-06-01 00:00:00
abstract::Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1283
更新日期:1994-06-01 00:00:00
abstract::We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1349
更新日期:1994-06-01 00:00:00
abstract::The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 anti...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.5.1061
更新日期:1994-05-01 00:00:00
abstract::Serum CASA, CEA, CYFRA 21-1, NSE, MSA, TPA, and TPS were determined in patients with lung cancer (LC), benign lung disease (BL), and healthy control (HC) donors. Using predefined cutpoints, the cytokeratin-related markers TPA, TPS, and CYFRA showed the highest sensitivity in non-small cell lung cancer (TPA 69%, TPS 63...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.5.1129
更新日期:1994-05-01 00:00:00
abstract::Previously we have demonstrated that the tumor infiltrating lymphocytes found in SJL/J mice with reticulum cell sarcomas (RCS) are CD4+ T cells which express T cell receptor (TCR) beta chain molecules comprised principally of Vbeta17a encoded variable gene segments. Herein we report both the cellular and molecular cha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.4.839
更新日期:1994-04-01 00:00:00
abstract::Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.4.903
更新日期:1994-04-01 00:00:00
abstract::Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.4.983
更新日期:1994-04-01 00:00:00
abstract::We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which cont...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.3.567
更新日期:1994-03-01 00:00:00
abstract::The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.3.633
更新日期:1994-03-01 00:00:00
abstract::Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.3.703
更新日期:1994-03-01 00:00:00
abstract::Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with both a total chromosome 16 library and with probe pHuR195 detecting loc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.347
更新日期:1994-02-01 00:00:00
abstract::Release of DNA fragments into the culture supernatant of human promyelocytic cell line HL-60 was investigated. The released DNA has previously been shown to have a strong immunosuppressive effect on the proliferation of mitogen-stimulated human peripheral lymphocytes and some cancer cell lines. In this study, HL-60 ce...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.417
更新日期:1994-02-01 00:00:00
abstract::To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.481
更新日期:1994-02-01 00:00:00
abstract::Expression of E-cadherin in esophageal carcinoma was studied immunohistochemically in 65 patients using an anti-human E-cadherin monoclonal antibody (HECD-1). In normal esophageal epithelium, E-cadherin was strongly expressed on cell-cell boundaries. On the contrary, a reduced E-cadherin expression (Rd-type) was frequ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The effect of reduced glutathione (GSH) and ethanol on aflatoxin B1 (AFB1)-induced DNA single strand breaks was studied in primary cultured hepatocytes. Buthionine sulfoximine (BSO) which decreased intracellular GSH to 13% of those of the control levels increased DNA fragmentation of AFB1-treated hepatocytes by over 1...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.1.123
更新日期:1994-01-01 00:00:00
abstract::E-cadherins are homophilic adhesion molecules the expression of which is tightly linked to the invasiveness and the differentiated state of the cells. E-cadherin expression seems also inversely related to the expression of vimentin, an intermediate filament implicated in the metastatic potential of some cells. In brea...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.1.181
更新日期:1994-01-01 00:00:00
abstract::Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.1.247
更新日期:1994-01-01 00:00:00
abstract::The purpose of this study was to determine whether the synthesis of endogenous nitric oxide (NO) is involved in the apoptosis of murine L929 transformed fibroblasts. L929 parental cells and L929 cells selected for resistance to tumor necrosis factor (TNF-alpha) were incubated in vitro with various concentrations of TN...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.6.1043
更新日期:1993-12-01 00:00:00
abstract::The proteins of the rho gene family have been isolated from cytosolic as well as particulate fractions. The rho proteins have values of about 22KDa and have consensus amino acid sequences for GTP/GDP-binding and GTPase activities. We have localized the rho proteins in mammalian cells by using affinity-purified anti-pe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.6.1103
更新日期:1993-12-01 00:00:00
abstract::To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::Lymphoid hyperplasia of lacrimal gland may be difficult to be differentiated from lymphomas on the basis of morphology and immunohistochemistry. The results of this study indicate that polymerase chain reaction should be employed for confirming the diagnosis of lymphoma in cases with histological and immunophenotypica...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.5.897
更新日期:1993-11-01 00:00:00
abstract::The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.5.963
更新日期:1993-11-01 00:00:00
abstract::In normal human somatic cells, gradual shortening of telomeres may activate the complex cascade of molecular events known as cellular senescence. Experimental evidence from our laboratory suggests that cellular mortality is regulated by two separate mechanisms that we have termed mortality stage 1 (M1) and mortality s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.559
更新日期:1993-10-01 00:00:00
abstract::One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.627
更新日期:1993-10-01 00:00:00
abstract::The relationship between mucin markers and several clinical and pathological characteristics was investigated in breast cancer tissue. CA549, CA15.3 and MCA were measured using commercially available assay methods in 82 primary breast carcinomas and 47 normal glandular breast tissue samples. Similarly to CA15.3 and MC...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.695
更新日期:1993-10-01 00:00:00
abstract::It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and nat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.763
更新日期:1993-10-01 00:00:00
abstract::The purpose of the study was to determine whether the organ environment can influence the response of colon cancer cells to chemotherapy. The highly metastatic human colon cancer cell line KM12L4, previously selected for production of liver metastases in nude mice, was injected into the cecal wall and into the spleen ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.3.413
更新日期:1993-09-01 00:00:00
abstract::Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Abstract. The gestational trophoblastic diseases (GTD) are uncommon complications of pregnancy. The UK GTD registration scheme offers specialist facilities for screening and treatment. In Sheffield about 5% of all patients monitored require chemotherapy. The successful treatment - almost 100% cure - of these patients ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.2.213
更新日期:1993-08-01 00:00:00
abstract::The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.2.337
更新日期:1993-08-01 00:00:00
abstract::We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.1.23
更新日期:1993-07-01 00:00:00
abstract::A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.1.81
更新日期:1993-07-01 00:00:00
abstract::A chromosomal break indicates a double-stranded DNA break of the chromatin fiber. Cytogenetic observations can enumerate chromosome breaks but cannot detect single-stranded DNA breaks (nicks). When a high frequency of chromosomal breaks occurs in a cell population, whether spontaneously occurred or mutagen induced, a ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.873
更新日期:1993-06-01 00:00:00
abstract::BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.937
更新日期:1993-06-01 00:00:00